芳香烃受体核转录蛋白样1抗体

中文名称：芳香烃受体核转录蛋白样1抗体

英文名称：BMAL1

别    名：ARNT like protein 1 brain and muscle; ARNTL; Aryl hydrocarbon receptor nuclear translocator like; Aryl hydrocarbon receptor nuclear translocator like protein 1; Aryl hydrocarbon receptor nuclear translocator-like protein 1; Basic helix loop helix PAS orphan MOP3; bHLH PAS protein JAP3; bHLHe5; BMAL 1; BMAL1c; Brain and muscle ARNT like 1; cycle; JAP 3; JAP3; Member of PAS protein 3; Member of PAS superfamily 3; MOP3; PAS domain-containing protein 3; PASD 3; PASD3; TIC.  

分 子 量：69kDa

细胞定位：细胞核 细胞浆

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.





产品介绍：生物钟振荡器的组成部分，包括 CRY 蛋白、CLOCK 或 NPAS2、ARNTL 或 ARNTL2、CSNK1D 和/或 CSNK1E、TIMELESS 和 PER 蛋白。 有效的 DNA 结合需要与另一种 bHLH 蛋白进行二聚化。 E-box 依赖性反式激活、CLOCK 核易位和降解以及 CLOCK 和 ARNTL 的磷酸化都需要使用 CLOCK 进行异二聚化。 与 PER 和 CRY 蛋白的相互作用需要易位到细胞核。 CLOCK-ARNTL 异二聚体与 PER 或 CRY 的相互作用抑制转录激活。 与 HSP90 相互作用； AHR 在体外，但不是在体内。

Function:
ARNTL-CLOCK heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins.

Subunit:
Interacts with CRY2. Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, ARNTL or ARNTL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH protein. Heterodimerization with CLOCK is required for E-box-dependent transactivation, for CLOCK nuclear translocation and degradation, and, for phosphorylation of both CLOCK and ARNTL. Interaction with PER and CRY proteins requires translocation to the nucleus. Interaction of the CLOCK-ARNTL heterodimer with PER or CRY inhibits transcription activation. Interacts with HSP90; with AHR in vitro, but not in vivo. Part of a nuclear complex which also includes GNB2L1/RACK1 and PRKCA; GNB2L1 and PRKCA are recruited to the complex in a circadian manner.

注意：
所提供的本产品仅供研究使用，不得用于人类、治疗或诊断应用。