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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
优利科(上海)生命科学有限公司
- 库存:
100
- 靶点:
详询
- 级别:
科研
- 目录编号:
/
- 克隆性:
多克隆
- 抗原来源:
详见说明书
- 保质期:
1年
- 抗体英文名:
Anti-Integrin Alpha V + Beta 5
- 抗体名:
Integrin Alpha V + Beta 5抗体
- 标记物:
详询
- 宿主:
兔
- 适应物种:
/
- 免疫原:
见产品详情
- 亚型:
IgG
- 形态:
冻干或液体
- 应用范围:
见产品详情
- 保存条件:
-20℃
- 浓度:
1mg/ml
- 规格:
详询
| 英文名称 Anti-Integrin Alpha V + Beta 5 | ||||||||||||||||
| 中文名称 整合素αVβ5抗体 | ||||||||||||||||
| 别 名 alpha 5; alpha polypeptide; CD49e; CD51; fibronectin receptor; FNRA; Integrin alpha V; Integrin beta 5; ITGA5; ITGAV; ITGB5; VLA5A; VNRA. | ||||||||||||||||
| 浓 度 1mg/1ml | ||||||||||||||||
| 规 格 0.1ml/100μg 0.2ml/200μg | ||||||||||||||||
| 抗体来源 Rabbit | ||||||||||||||||
| 克隆类型 polyclonal | ||||||||||||||||
| 交叉反应 Human, Mouse, Rat | ||||||||||||||||
| 产品类型 一抗 | ||||||||||||||||
研究领域 细胞生物 干细胞 细胞粘附分子 ![]() |
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| 蛋白分子量 predicted molecular weight: 88/121kDa | ||||||||||||||||
| 性 状 Lyophilized or Liquid | ||||||||||||||||
| 免 疫 原 KLH conjugated synthetic peptide derived from human Integrin beta 5 and Integrin alpha V C-terminus | ||||||||||||||||
| 亚 型 IgG | ||||||||||||||||
| 纯化方法 affinity purified by Protein A | ||||||||||||||||
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide | ||||||||||||||||
| 产品应用 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 | ||||||||||||||||
| (石蜡切片需做抗原修复) | ||||||||||||||||
| not yet tested in other applications. | ||||||||||||||||
| optimal dilutions/concentrations should be determined by the end user. | ||||||||||||||||
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. ![]() |
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| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. | ||||||||||||||||
| 产品介绍 Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metatastatic diffusion of tumour cells. ITAGV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. The I-domain containing integrin alpha V undergoes post-translational cleavage to yield disulfide-linked heavy and light chains, that combine with multiple integrin beta chains to form different integrins. Among the known associating beta chains (beta chains 1,3,5,6, and 8; ITGB1, ITGB3, ITGB5, ITGB6, and ITGB8), each can interact with extracellular matrix ligands; the alpha V beta 3 integrin, perhaps the most studied of these, is referred to as the Vitronectin receptor (VNR). In addition to adhesion, many integrins are known to facilitate signal transduction. | ||||||||||||||||
| 整合素αVβ3、αVβ5是特异性表达在血管内皮细胞表面的粘附因子,在介导内皮细胞和ECM相互接触中起作用。 | ||||||||||||||||
整合素(integrin)分布广泛,属于细胞黏附分子家族。经研究发现整合素可以调节细胞-细胞、细胞-细胞外基质(extracellular matrix,ECM〕间的黏附。整合素所介导的肿瘤细胞与ECM间的相互作用影响肿瘤的发生、增殖、侵袭和转移到其他组织的能力。
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