别 名:BR serine/threonine kinase 1; BR serine/threonine protein kinase 1; BR serine/threonine-protein kinase 1; Brain-specific serine/threonine-protein kinase 1; BRSK 1; Brsk1; BRSK1_HUMAN; Protein kinase SAD1A; SAD 1; SAD1; SAD1 kinase; SAD1A; SADB; SadB kinase short isoform; Serine/threonine kinase SAD B; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog; FLJ43009; KIAA1811.
分 子 量:86kDa
细胞定位:细胞核 细胞浆 细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:前脑神经元极化所必需的,它赋予轴突和树突不同的特性,可能通过局部调节微管相关蛋白的磷酸化(通过相似性)。 可能参与调节 G2/M 阻滞以响应 UV 或甲基/磺酸盐 (MMS) 诱导的 DNA 损伤,但不参与 IR 诱导的 DNA 损伤。 在体外磷酸化 WEE1 和 CDC25B,在体外和体内磷酸化 CDC25C。 组织特异性:广泛表达,在大脑和睾丸中含量最高。 蛋白质水平在整个细胞周期中保持不变。
Subcellular Location: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, centrosome. Cell junction, synapse. Note=Localizes to synaptic vesicles in neurons. Nuclear in the absence of DNA damage. Translocated to the nucleus in response to UV- or MMS-induced DNA damage.
Tissue Specificity: Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle.