储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:在人肝细胞溶质组分中,已鉴定出四种形式的胆绿素还原酶,包括两种胆绿素-IX β 还原酶和两种胆绿素-IX α 还原酶,分别称为同工酶 I 和 II 以及同工酶 III 和 IV。 胆绿素还原酶 A (BLVRA),也称为胆绿素-IX α-还原酶,属于 GFO/iIDH/MocA 家族和胆绿素还原酶亚家族。 编码这种细胞质蛋白的基因映射到染色体 7p14-cen。 BLVRA 将胆绿素 IX(开放四吡/咯的亚甲基桥)还原为胆红素,同时氧化 NADH 或 NADPH 辅因子(胆红素 + NADP+ = 胆绿素 + NADPH)。 BLVRA 主要在肝脏中表达。
Function: Biliverdin Reductase (BVR) catalyzes the final step in the heme metabolic pathway, the reduction of biliverdin IX{alpha} to bilirubin, with the concomitant oxidation of a NADH or NADPH cofactor. The enzyme remains unique among all biological catalysts described to date in having a dual pH/cofactor-dependent activity profile. Human biliverdin reductase (hBVR) has been recently shown to be a Ser/Thr/Tyr kinase in the MAPK insulin/insulin-like growth factor 1 (IGF1)-signaling cascade. BVR together with its substrate, biliverdin, and product, bilirubin, have recently been revealed to be important players in cellular signal transduction pathways, gene expression and oxidative response. These features make BVR unusually interesting and unique among all enzymes characterized to date.