Anti-IMPACT Polyclonal Antibod

Anti-IMPACT Polyclonal Antibody



产品简介

靶标	IMPACT
别名	RWDD5;IMPACT
宿主	Rabbit
预测交叉反应	Bovine;Zebrafish;Rabbit
稀释比例	WB 1:1000-3000.
Gene ID	55364
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9P2X3
蛋白分子量	23/36kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	Recombinant protein of human IMPACT
亚型	IgG
纯化方法	Affinity purification
背景资料	Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
Public Immunogen Range	1-321aa
克隆类型	Polyclonal Antibody
应用	WB
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with IMPACT antibody diluted at 1:2000;Lane:Caski,Human stomach cancer