Anti-INTS3 Polyclonal Antibody

Anti-INTS3 Polyclonal Antibody


产品简介

靶标	INTS3
别名	C1orf193; C1orf60; FLJ21919; INT 3; Int3; INT3_HUMAN; Integrator complex subunit 3; Ints3; Sensor of single-strand DNA complex subunit A; Sensor of ssDNA subunit A; SOSS complex subunit A; SOSS-A
宿主	Rabbit
预测交叉反应	Zebrafish;Fruit fly
稀释比例	IHC 1:50-200.
Gene ID	65123
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q68E01
蛋白分子量	64/103/118kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Nucleus Cytoplasm Nucleus
免疫原	Recombinant protein of human INTS3
亚型	IgG
纯化方法	Affinity purification
背景资料	Component of the Integrator (INT) complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
Public Immunogen Range	1-349aa
克隆类型	Polyclonal Antibody
交叉反应	Human;Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human stomach cancer with INTS3 antibody diluted at 1:80.