Anti-PAK5 Polyclonal Antibody

Anti-PAK5 Polyclonal Antibody



产品简介

靶标	PAK5
别名	Serine/threonine-protein kinase PAK 5;p21-activated kinase 5;PAK-5;p21-activated kinase 7;PAK-7;KIAA1264;PAK7;
宿主	Rabbit
稀释比例	IHC 1:100-300.
Gene ID	57144
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q9P286
蛋白分子量	81kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	Recombinant protein of human PAK5
亚型	IgG
纯化方法	Affinity purification
背景资料	Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.
Public Immunogen Range	1-350aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human endometrial cancer using PAK5 antibody diluted at 1:200