Anti-GET3 Polyclonal Antibody

Anti-GET3 Polyclonal Antibody



产品简介

靶标	GET3
别名	ASNA1;ARSA-I;ARSA1;ASNA-I;GET3;TRC40;hASNA-I
宿主	Rabbit
稀释比例	IHC 1:50-200.
Gene ID	439
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	O43681
蛋白分子量	39kDa
储存液	Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Nucleus
免疫原	Recombinant protein of human GET3
亚型	IgG
纯化方法	Affinity purification
背景资料	ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity). May be involved in insulin signaling.
Public Immunogen Range	1-348aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human breast cancer using GET3 antibody diluted at 1:100