Anti-FBXW4 Polyclonal Antibody

Anti-FBXW4 Polyclonal Antibody


产品简介

英文名称	Anti-FBXW4 Polyclonal Antibody
别名	FBXW4;DAC;FBW4;FBWD4;SHFM3;SHSF3
宿主	Rabbit
稀释比例	WB 1:8000-12000. IHC 1:50-200.
Gene ID	6468
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P57775
蛋白分子量	46kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	Recombinant protein of human FBXW4
亚型	IgG
纯化方法	Affinity purification
背景资料	This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22.
Public Immunogen Range	1-293aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human pancreatic cancer using FBXW4 antibody diluted at 1:100

Western blot analysis with FBXW4 antibody diluted at 1:10000;Lane: MCF7,HepG2,A549,THP-1