K200104M Anti-CHI3L1 Monoclona

【抗体靶点简介】

Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung.

【实验操作视频参考】

Western blot实验参考操作流程

Immunohistochemistry实验参考操作流程

抗体在科研领域应用十分广泛，对解析生物学过程、探究疾病发病机制、创新药物研发与临床治疗研究均起到关键支撑作用。

索莱宝现有30000余种经过严格实验验证的抗体产品，全面覆盖神经科学、细胞凋亡、表观遗传学等热门研究方向，适配 WB、IHC、ELISA、IP、co-IP 等主流实验技术场景。包括内参标签抗体，以及多种标记类型的一抗、二抗，充分满足客户多样化实验选型需求。索莱宝拥有成熟专业的抗体制备与质量检测平台，从免疫制备、纯化提纯到实验验证全流程严格筛选评估，全方位保障每一支抗体的性能与品质。

此外，索莱宝已完善一站式技术服务平台，可提供 WB、IHC、IF、IP、流式检测、细胞实验等常规检测，以及多克隆/单克隆抗体定制等个性化定制服务，为科研用户提供全方位解决方案。