Anti-OPRK1 Polyclonal Antibody

Anti-OPRK1 Polyclonal Antibody

 

 产品简介

宿主	Rabbit
稀释比例	WB 1:8000-12000. IHC 1:100-300.
Gene ID	4986
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P41145
蛋白分子量	33/42kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm
免疫原	A synthetic peptide of human OPRK1
亚型	IgG
纯化方法	Octanoic acid-ammonium sulfate precipitation
Important Note	Important Note
背景资料	G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Public Immunogen Range	330-380/380aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	WB IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Western blot analysis with OPRK1 antibody diluted at 1:10000;Lane: Mouse brain

Immunohistochemistry of paraffin-embedded Human colorectal cancer with OPRK1 antibody diluted at 1:200