Anti-ZFP36L2 Polyclonal Antibo

Anti-ZFP36L2 Polyclonal Antibody


产品简介

英文名称	Anti-ZFP36L2 Polyclonal Antibody
别名	BRF2;Butyrate response factor 2;C3H1 type-like 2;EGF response factor 2;EGF-response factor 2;ERF 2;ERF-2;ERF2;Protein TIS11D;RNF162C;TIS11D;TISD_HUMAN;ZFP36 like 2;ZFP36 ring finger protein like 2;ZFP36-like 2;Zfp36l2;Zinc finger protein 36;Zinc finger protein 36, C3H type like 1;zinc finger protein 36, C3H type like 2;Zinc finger protein 36, C3H1 type like 2;Zinc finger protein, C3H type, 36 like 2;
宿主	Rabbit
稀释比例	IHC 1:25-100.
Gene ID	678
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	P47974
蛋白分子量	51kDa
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
亚细胞定位	Cytoplasm Cell membrane
免疫原	A synthetic peptide of Human ZFP36L2
亚型	IgG
纯化方法	Affinity purification
背景资料	Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:25106868, PubMed:14981510). Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:25106868). Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes (PubMed:25106868). Binds to 3'-UTR ARE of numerous mRNAs (PubMed:20506496, PubMed:25106868, PubMed:14981510). Promotes ARE-containing mRNA decay of the low-density lipoprotein (LDL) receptor (LDLR) mRNA in response to phorbol 12-myristate 13-acetate  treatment in a p38 MAPK-dependent manner (PubMed:25106868). Positively regulates early adipogenesis by promoting ARE-mediated mRNA decay of immediate early genes (IEGs). Plays a role in mature peripheral neuron integrity by promoting ARE-containing mRNA decay of the transcriptional repressor REST mRNA. Plays a role in ovulation and oocyte meiotic maturation by promoting ARE-mediated mRNA decay of the luteinizing hormone receptor LHCGR mRNA. Acts as a negative regulator of erythroid cell differentiation: promotes glucocorticoid-induced self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. In association with ZFP36L1 maintains quiescence on developing B lymphocytes by promoting ARE-mediated decay of several mRNAs encoding cell cycle regulators that help B cells progress through the cell cycle, and hence ensuring accurate variable-diversity-joining (VDJ) recombination process and functional immune cell formation. Together with ZFP36L1 is also necessary for thymocyte development and prevention of T-cell acute lymphoblastic leukemia (T-ALL) transformation by promoting ARE-mediated mRNA decay of the oncogenic transcription factor NOTCH1 mRNA.
Public Immunogen Range	220-270/494aa
克隆类型	Polyclonal Antibody
交叉反应	Human
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human colorectal cancer with ZFP36L2 antibody diluted at 1:80