Anti-E2F4 Polyclonal Antibody

Anti-E2F4 Polyclonal Antibody

产品简介

英文名称	Anti-E2F4 Polyclonal Antibody
靶标	E2F/5
别名	E2F 4;E2F transcription factor 4;E2F transcription factor 4 p107/p130 binding;E2F-4;E2F4;E2F4_HUMAN;p107/p130 binding protein;Transcription factor E2F 4;Transcription factor E2F4
宿主	Rabbit
稀释比例	IHC 1:50-200.
Gene ID	1874
保存	Store at -20°C. Avoid freeze / thaw cycles.
Swiss Prot	Q16254
储存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
蛋白分子量	44kDa
亚细胞定位	Nucleus
免疫原	A synthetic peptide of Human E2F4
亚型	IgG
纯化方法	Affinity purification
背景资料	The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein binds to all three of the tumor suppressor proteins pRB, p107 and p130, but with higher affinity to the last two. It plays an important role in the suppression of proliferation-associated genes, and its gene mutation and increased expression may be associated with human cancer. [provided by RefSeq, Jul 2008]
Public Immunogen Range	340-390/413aa
克隆类型	Polyclonal Antibody
交叉反应	Human Rat Mouse
应用	IHC
规格	50ul 100ul

备注：
以上数据均来自公开文献, Solarbio暂未进行独立验证, 仅供参考。
These protocols are for reference only. Solarbio does not independently validate these methods.
实验图

Immunohistochemistry of paraffin-embedded Human thyroid cancer with E2F4/5 antibody diluted at 1:100