别 名:APS; Adaptor protein with pleckstrin homology and src homology 2 domains; SH2 and PH domain containing adapter protein APS; SH2B2_HUMAN; SH2B adapter protein 2; Adapter protein with pleckstrin homology and Src homology 2 domains; SH2 and PH domain-containing adapter protein APS.
分 子 量:68kDa
细胞定位:细胞浆 细胞膜
纯化方法:affinity purified by Protein A
储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:该基因编码的蛋白质在 B 淋巴细胞中表达,并包含 pleckstrin 同源性和 src 同源性 2 (SH2) 结构域。 在伯基特淋巴瘤细胞系中,它响应 B 细胞受体刺激而被酪氨酸磷酸化。 因为它与刺激无关地结合 Shc 和刺激后的 Grb2,它似乎在从受体到 Shc/Grb2 途径的信号转导中起作用。
Function: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3.