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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IFT20
- 抗体名：
IFT20抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
冻干或液体
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IFT20 |
| 中文名称 细胞纤毛内转运同源蛋白20抗体 |
| 别 名 hIFT20; Intraflagellar transport 20 homolog (Chlamydomonas); Intraflagellar transport protein 20 like; IFT20_HUMAN; Intraflagellar transport protein IFT20. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 信号转导  |
| 蛋白分子量 predicted molecular weight: 15kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IFT20 |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 IFT20 is a gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14. |
| Function : Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium. |
| Subunit : Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20. Interacts directly with IFT57 and KIF3B/Kinesin II subunit (By similarity). Interacts with CCDC41/CEP83. |
| Subcellular Location : Golgi apparatus, cis-Golgi network (By similarity). Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia (By similarity). |
| Tissue Specificity : Expressed in almost all tissues. |
Database links : UniProtKB/Swiss-Prot: Q8IY31.1 |
| Anti-mucin-1/Muc-1/CD227 antigen (Epithelial Membrane Antigen ) 粘蛋白-1/上皮膜抗原抗体 |
| Anti-MyD88 (myeloid differential protein-88) 髓样分化蛋白抗体 |
| Anti-Myelin P0 protein( peripheral myelin prothein Zero;MPZ;MPP) 外周髓磷脂P0蛋白/P0蛋白抗体 |
| Anti-Myosin (Smooth Muscle) 鼠抗人心肌肌凝蛋白(平滑肌) 单抗 |
| Anti-N-AChR α4 (Nicotinic-Acetylcholine receptor α4) 碱型乙酰胆碱受体α4抗体 |
| Anti-N-AChR α7 (Nicotinic-Acetylcholine receptor α7) 碱型乙酰胆碱受体α7抗体 |
| Anti-Nanog 胚胎干细胞关键蛋白抗体 |
| anti-Natrexone 抗纳曲酮抗体IgG |
| Anti-NAP1 (nucleosome assembly protein 1) 核小体组装蛋白1抗体 |
| Anti-N-cadherin N-钙粘附分子抗体 |
| Anti-N-coR1 （Nuclear receptor co-repressor 1） 核受体辅助抑制因子抗体 |
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文献和实验【摘要】目的探讨嵌合抗CD20抗体Fab’片段的抗肿瘤机制。方法应用MTT法检测Fab’片段对Raji细胞生长的抑制作用，用Annexin V-FITC和PI测定Fab’片段对Raji细胞凋亡的诱导作用，用RT-PCR和Western blot检测Raji细胞中bcl-2表达的变化。结果嵌合抗CD20Fab’片段对Raji细胞具有明显的抑制作用IC50值为24.2 µg/ml，并呈剂量依赖性；嵌合抗CD20Fab’片段能诱导Raji细胞的凋亡，并降低Raji细胞中bcl-2基因及其蛋白的表达
、14.6μg/ml）低于Fab’对Raji、Daudi的IC50（45.9μg/ml、39.5μg/ml）。Fab'（50mg/kg，i.v.）和F（ab’）2(50mg/kg，i.p.）对荷瘤鼠瘤块体积的增长有抑制作用。结论 实现了直接在大肠杆菌中高效可溶性分泌表达有活性的抗CD20嵌合抗体Fab’和F（ab’）2的目的。Fab’适于显象，F（ab）2片段的抑制肿瘤生长活性明显高于Fab’，半衰期长于Fab’，更适于治疗。【关键词】B淋巴细胞瘤嵌合抗体Fab’片段 嵌合抗体F（ab）2片段CD20B淋巴细胞
Nature：浙大陈才勇团队首次发现细胞内血红素分子伴侣 HRG-9 和 TANGO2
室在 Nature 发表了题为 HRG-9 homologues regulate haem trafficking from haem-enriched compartments 的文章，揭示了一个新的细胞内血红素伴侣蛋白 HRG-9（heme responsive gene-9）。在秀丽线虫中，HRG-9 及其同源蛋白 HRG-10 将血红素转运出其贮存部位——溶酶体相关细胞器；而在人、斑马鱼、酵母等能自身合成血红素的生物中，HRG-9 的同源蛋白 TANGO2 将血红素运出其合成部位——线粒体。 为了研究
