储 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
产品介绍:Beta 2 肾上/腺素受体是 G 蛋白偶联受体超家族的成员。 该受体与其最终效应器之一直接相关,即 C L 类钙通道 Ca(V)1.2。 该受体通道复合物还包含 G 蛋白、腺苷酸环化酶、cAMP 依赖性激酶和平衡磷酸酶 PP2A。 信号复合物的组装提供了一种机制,可确保该 G 蛋白偶联受体的特异性和快速信号传导。 该基因在其编码或非翻译序列中均不含内含子。 该基因的不同多态形式、点突变和/或下调与夜间哮喘、肥胖和 2 型糖尿病有关。 已报道在脂肪、血液、脑、心脏、肺、鼻、胰腺、骨骼肌、皮肤和血管中表达 2 肾上/腺素能受体。
Function: Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.
Subunit: Binds SLC9A3R1 and GPRASP1. Interacts with ARRB1 and ARRB2. Interacts with SRC, USP20 and USP33. Interacts with VHL; the interaction, which is increased on hydroxylation of ADRB2, ubiquitinates ADRB2 leading to its degradation. Interacts with EGLN3; the interaction hydroxylates ADRB2 facilitating VHL-E3 ligase-mediated ubiquitination.