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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
优利科（上海）生命科学有限公司
- 库存：
100
- 靶点：
详询
- 级别：
科研
- 目录编号：
/
- 克隆性：
多克隆
- 抗原来源：
详见说明书
- 保质期：
1年
- 抗体英文名：
Anti-IL-7Ra/CD127
- 抗体名：
IL-7Ra/CD127抗体
- 标记物：
详询
- 宿主：
兔
- 适应物种：
/
- 免疫原：
见产品详情
- 亚型：
IgG
- 形态：
冻干或液体
- 应用范围：
见产品详情
- 保存条件：
-20℃
- 浓度：
1mg/ml
- 规格：
详询
| 英文名称 Anti-IL-7Ra/CD127 |
| 中文名称 白细胞介素-7受体a抗体 |
| 别 名 Interleukin-7 receptor-alpha; IL7R alpha ; IL7R; CD127; CDW127; IL-7R-alpha; IL7RA; ILRA. |
| 浓 度 1mg/1ml |
| 规 格 0.2ml/200μg |
| 抗体来源 Rabbit |
| 克隆类型 polyclonal |
| 交叉反应 Human, Mouse, Rat, Horse, Rabbit |
| 产品类型 一抗 |
研究领域 细胞生物 免疫学 发育生物学 干细胞 淋巴细胞 t-淋巴细胞 b-淋巴细胞  |
| 蛋白分子量 predicted molecular weight: 50kDa |
| 性 状 Lyophilized or Liquid |
| 免 疫 原 KLH conjugated synthetic peptide derived from human IL-7Ra N-terminus |
| 亚 型 IgG |
| 纯化方法 affinity purified by Protein A |
| 储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide |
| 产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 |
| （石蜡切片需做抗原修复） |
| not yet tested in other applications. |
| optimal dilutions/concentrations should be determined by the end user. |
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.  |
| Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品介绍 The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). |
| Function : Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP). |
| Subcellular Location : Secreted and Cell membrane. |
| Post-translational modifications : N-glycosylated IL-7Ralpha binds IL7 300-fold more tightly than the unglycosylated form. |
| DISEASE : Defects in IL7R are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (T(-)B(+)NK(+) SCID) [MIM:608971]. A form of severe combined immunodeficiency (SCID), a genetically and clinically heterogeneous group of rare congenital disorders characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Patients present in infancy recurrent, persistent infections by opportunistic organisms. The common characteristic of all types of SCID is absence of T-cell-mediated cellular immunity due to a defect in T-cell development. |
| Genetic variations in IL7R are a cause of susceptibility to multiple sclerosis type 3 (MS3) [MIM:612595]. A multifactorial, inflammatory, demyelinating disease of the central nervous system. Sclerotic lesions are characterized by perivascular infiltration of monocytes and lymphocytes and appear as indurated areas in pathologic specimens (sclerosis in plaques). The pathological mechanism is regarded as an autoimmune attack of the myelin sheat, mediated by both cellular and humoral immunity. Clinical manifestations include visual loss, extra-ocular movement disorders, paresthesias, loss of sensation, weakness, dysarthria, spasticity, ataxia and bladder dysfunction. Genetic and environmental factors influence susceptibility to the disease. Note=A polymorphism at position 244 strongly influences susceptibility to multiple sclerosis. Overtransmission of the major 'C' allele coding for Thr-244 is detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS. |
| Similarity : Belongs to the type I cytokine receptor family. Type 4 subfamily. |
Contains 1 fibronectin type-III domain. |
| HSP-90β （heat sock protein-90β） 热休克蛋白-90β （抗原） |
| IASPP(inhibitory member of the ASPP family) 肿瘤细胞凋亡ASPP家族的另一个成员(抗原) |
| CD54 ICAM-1 (InteYTellular dhesion molecule 1; CD54 antigen;) 细胞间粘附分子-1(多肽抗原) |
| IL-1β(Interleukin-1β) 白介素1β（白细胞介素-1β）(多肽抗原) |
| IL1RAPL1 （Interleukin 1 receptor accessory protein-like 1） 白介素受体相关蛋白样1前体蛋白（抗原） |
| IL-6(Interleukin-6) 白介素6（白细胞介素-6）(多肽抗原) |
| IL-10(Interleukin-10) 白介素10（白细胞介素-10）(抗原) |
| IL-10(Interleukin-10) 白介素10（白细胞介素-10）(抗原) |
| IL-8 白介素8（白细胞介素-8）(抗原) |
| Insulin Receptor（ISR） 胰岛素受体（抗原） |
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白细胞介素-7受体a抗体
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