芳香胺N-乙酰化转移酶抗体

中文名称：芳香胺N-乙酰化转移酶抗体

英文名称：AANAT

别    名：SNAT_HUMAN; AANAT; Arylalkylamine N acetyltransferase; Serotonin N-acetyltransferase; SNAT.  

货号：YLK-KT0750
 

分 子 量：23kDa

细胞定位：细胞浆 

纯化方法：affinity purified by Protein A

储 存 液：0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.




 

产品介绍：该基因编码的蛋白质属于乙酰转移酶超家族。 它是褪黑激素合成中倒数第二的酶，并控制脊椎动物松果体中褪黑激素产生的昼夜节律。 褪黑激素对于影响活动和睡眠的生物钟功能至关重要。 这种酶由 cAMP 依赖性磷酸化调节，促进其与 14-3-3 蛋白的相互作用，从而保护酶免受蛋白酶体降解。 该基因可能导致许多遗传疾病，例如延迟睡眠期综合症。 已发现该基因的编码不同同种型的剪接转录变体。

Function:
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.

Subunit:
Monomer (By similarity). Interacts with several 14-3-3 proteins, including YWHAB, YWHAE, YWHAG and YWHAZ, preferentially when phosphorylated at Thr-31. Phosphorylation on Ser-205 also allows binding to YWHAZ, but with lower affinity. The interaction with YWHAZ considerably increases affinity for arylalkylamines and acetyl-CoA and protects the enzyme from dephosphorylation and proteasomal degradation (By similarity). It may also prevent thiol-dependent inactivation (By similarity).

注意：
所提供的本产品仅供研究使用，不得用于人类、治疗或诊断应用。