Verrucarin J,4643-58-7

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Verrucarin J

CAS No. : 4643-58-7

MCE 国际站：Verrucarin J

产品活性：Verrucarin J (Muconomycin B) 是 Myrothecium 真菌家族的代谢物。Verrucarin J 诱导活性氧 (ROS) 生成和癌细胞系凋亡 (apoptosis)，例如 A549、HCT 116 和 SW-620 细胞。Verrucarin J 具有抗 Candida albicans 和 Mucor miehei 的活性。Verrucarin J 抑制沙粒病毒 Junin (JUNV) 产量，IC₅₀ 为 1.2 ng/mL。

研究领域：Apoptosis  |  Anti-infection  |  Immunology/Inflammation  |  NF-κB  |  Metabolic Enzyme/Protease

作用靶点：Apoptosis  |  Arenavirus  |  Fungal  |  Antibiotic  |  Reactive Oxygen Species

In Vitro: Verrucarin J (0, 5, 10, 20, 50 nM; 24 hours) induces the apoptosis of A549 cells.
Verrucarin J (0, 1, 2, 5, 10, 20, 50 nM; 24, 48, 72 hours) significantly inhibits cell proliferation of A549 and H1793 cells with IC₅₀ values of approximately 10 nM and 20 nM after 48 h of treatment, respectively.
Verrucarin J (0, 0.1, 0.2, 0.3, 0.4, 0.5 μM; 24 hours) has an IC₅₀ of 300 nM for HCT 116 and SW-620 cell proliferation.
Verrucarin J (0, 10, 20 nM, 48 hours) inhibits cancer stem cell (CSC) self-renewal pathways Wnt1/β-catenin and Notch1 and down-regulates the expression of key CSC specific genes (ALDH1, LGR5, OCT4 and CD133) of A549 cells.
Verrucarin J (compound 2; 50 μg/disk) shows noteworthy activities against Candida albicans and Mucor miehei.
Verrucarin J reduces JUNV yield more than 2 log units and has a similar effect against the arenavirus Tacaribe.
Verrucarin J reduces the cell viability of Vero cells with a cytotoxic concentration 50% (CC₅₀) of 8.2 ng/mL.

In Vivo: Verrucarin J (0.5 mg/kg; i.p. for 4 weeks) suppresses AKT-induced tumor growth in a xenograft model.
Verrucarin J (0.1, 0.5, 2.0 mg/kg; i.p. for three weeks) is a highly potent anticancer drug and suppresses tumor growth and metastasis.

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