sEH inhibitor-1,1208549-68-1

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sEH inhibitor-1

CAS No. : 1208549-68-1

MCE 国际站：sEH inhibitor-1

产品活性：sEH inhibitor-1 (compound TCPU ) 是一种有效的口服活性可溶性环氧化物水解酶 (sEH) 抑制剂，在人和鼠中的 IC₅₀s 分别为 0.4 和 5.3 nM。

研究领域：Metabolic Enzyme/Protease

作用靶点：Epoxide Hydrolase

In Vivo: Pharmacokinetic parameters of sEH inhibitor-1 (TCPU) after oral gavage with a non-compartmental analysis.

Doses (mg/kg)	Cmaxa (nmol/L)	Tmax (h)a	AUCt (uM•h)a	MRT (h)a
0.1 (0.27d)	270±120	5.3±1.2	2.2±1.1	18.9±6.6
0.3 (0.81d)	1680±1170	4.7±1.2	16.6±8.8	16.9±5.4
1.0 (2.69d)	2560±95	3.2±2.2	43.8±5.1	24.0±1.8
3.0 (8.08d)	5160±265	3.9±2.5	94.3±8.0	32.1±5.6

a: T_max, the time of maximum concentration; C_max, the maximum blood concentration; MRT, the mean residence time; and AUC_t, area under the concentration–time curve to terminal time. Additional PK parameters with non-compartmental model are presented in Table S3.
d: The dose with the unit of μmol/kg.

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