sEH inhibitor-12

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sEH inhibitor-12

CAS No. :

MCE 国际站：sEH inhibitor-12

产品活性：sEH inhibitor-12 (compound 34) 是 sEH 的抑制剂，IC₅₀ 值为 0.7 μM。sEH inhibitor-12 抑制 5-脂氧合酶激活蛋白 (FLAP) 介导的白三烯 (LT) 合成，IC₅₀ 值为 2.9 μM。sEH inhibitor-12 可用于炎症的研究。

研究领域：Metabolic Enzyme/Protease

作用靶点：Epoxide Hydrolase

In Vitro: sEH inhibitor-12 (0-10 μM; 10 min) inhibits sEH activity with an IC₅₀ value of 0.7 μM.
sEH inhibitor-12 (0-10 μM) inhibits FLAP-mediated cellular LT formation with an IC₅₀ value of 2.9 μM.
sEH inhibitor-12 (15 min) remains the activity of 5-lipoxygenase (5-LO) product formation in neutrophils with 84.5% and 4.5% at doses of 1 and 10 μM, respectively.

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