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- 详细信息
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture
- 英文名：
VOB560 hydrochloride
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1644543-95-2
- 规格：
10 mM * 1 mL/1 mg/5 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥ |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥2000.0 |
| 规格： | 5 mg | 产品价格： | ￥5000.0 |
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S65487 hydrochloride
CAS No. : 1644543-95-2
MCE 国际站：S65487 hydrochloride
产品活性：S65487 (VOB560) hydrochloride 是一种有效的选择性 Bcl-2 抑制剂，是 S55746 的前体。S65487 hydrochloride 对 BCL-2 突变也有活性，例如 G101V 和 D103Y。S65487 hydrochloride 对 MCL-1，BFL-1 和 BCL-XL 的亲和力较差。S65487 hydrochloride 诱导细胞凋亡 (apoptosis) 并具有抗癌活性。
研究领域：Apoptosis
作用靶点：Bcl-2 Family | Apoptosis
In Vitro: S65487 hydrochloride binds to the BH3 hydrophobic groove of BCL-2. S65487 hydrochloride induces apoptosis in a panel of hematological cancer cell lines and inhibits cell proliferation with IC50s in the low nM range.
In Vivo: S65487 hydrochloride induces complete regression in BCL-2-dependent RS4;11 tumors in vivo after a single IV (intravenous) administration. Strong and persistent tumor regression in xenograft models of lymphoid malignancies in mouse and rat are observed at well tolerated doses following weekly IV administration of S65487 hydrochloride in combination with the MCL-1-specific inhibitor, S64315/MIK665.
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