Mal-PEG8-amide-Val-Ala-(4-NH2)

Development and Clinical Application in Arthritis of a New Immunoassay for Serum Type IIA Procollagen NH2 Propeptide

Type II collagen, the most abundant protein of cartilage matrix, is synthesized as a procollagen molecule including the N-(PIINP) and C-(PIICP) propeptides at each end. Type II procollagen is produced in two forms as the result of alternative

Modulation of G Proteins in Rat Striatum by Neuroleptic Drugs and a Peptidomimetic Analog of Pro-Leu-Gly-NH2

Although the dopamine hypothesis of schizophrenia has gained wide acceptance, it has recently become clear that it requires revision (Seeman and Niznik, 1990 ; Ellison, 1994 ; Kahn and Davis, 1995 ). The original hypothesis asserts

通过序列设计解决关于多肽的一些问题

带正电荷），我们推荐多肽为这样的形式：H-peptide-amide（多肽N端自由氨基，C端酰胺化），以使多肽尽可能多的带正电荷。2. 缩短或延长多肽序列如果序列中疏水性残基（W、F、V、I、L、M、Y、A）的含量大于50%时，多肽的溶解性显著降低。此时，延长序列增加的极性残基往往有助于提高多肽的极性。相反，缩短序列以减少疏水性残基也能增强多肽的极性。总之，多肽的极性越强，其水溶性越好。3. 增加亲水性残基为了改善多肽的溶解性，有些多肽序列是可以任意添加一些极性残基的。我们建议