Dacomitinib-d10 dihydrochlorid

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Dacomitinib-d10 dihydrochloride

CAS No. :

MCE 国际站：Dacomitinib-d10 dihydrochloride

产品活性：Dacomitinib-d₁₀ (dihydrochloride) 是 Dacomitinib dihydrochloride 的氘代物。Dacomitinib (PF-00299804) dihydrochloride 是一种特异，不可逆的 ERBB 家族抑制剂，作用于 EGFR，ERBB2 和 ERBB4 的 IC₅₀ 分别为 6 nM，45.7 nM 和 73.7 nM

研究领域：Others  |  JAK/STAT Signaling  |  Protein Tyrosine Kinase/RTK  |  Apoptosis

作用靶点：Isotope-Labeled Compounds  |  EGFR  |  Apoptosis

In Vitro: Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

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