GW 9578,247923-29-1

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GW 9578

CAS No. : 247923-29-1

MCE 国际站：GW 9578

产品活性：GW9578 是一种亚型选择性的 PPARα 激动剂 (对鼠和人 PPAR-α 的 EC₅₀ 分别为 5 和 50 nM)，具有有效的降脂活性。

研究领域：Cell Cycle/DNA Damage  |  Vitamin D Related/Nuclear Receptor

作用靶点：PPAR

In Vitro: GW9578 exhibits activities on Murine PPAR-α, PPAR-γ, and PPAR-δ with EC₅₀s of 0.005, 1.5, 2.6 μm, respectively. GW9578 exhibits activities on Human PPAR-α, PPAR-γ, and PPAR-δ with EC₅₀s of 0.05, 1, and 1.4 μm, respectively.
Treatment of the CD8⁺ T-cell line, TK.1 cells with GW9578 (10 nM-1 μM; for 24 hours) is able to induce a dose-dependent increase in the amount of relative luciferase activity.
Treatment of murine T-cell thymoma EL-4 T cells with GW9578 (10 nM-10 μM; for 2 hours) leads to a significant decrease in IL-2 production compared with control cells.

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