UPCDC-30245,1883351-01-6

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UPCDC-30245

CAS No. : 1883351-01-6

MCE 国际站：UPCDC-30245

产品活性：UPCDC-30245 是一种变构 p97 (allosteric p97) 抑制剂，IC₅₀ 约为 27 nM。UPCDC-30245 抑制 p97 突变体 N660K 的效力与野生型 (IC₅₀=300 nM) 相似，此外对 p97 突变体 T688A 仅表现出 3 倍的耐药性。UPCDC-30245可用于癌症研究。

研究领域：Cell Cycle/DNA Damage

作用靶点：p97

In Vitro: UPCDC-30245 binds at the junction between the D1 dan D2 domains of p97.
?UPCDC-30245 inhibits cell proliferation in HeLa, A549, BxPC-3, PRMI8226, MM1S, HCT116 cells, and appears more potent in HT29 cells.
?UPCDC-30245 (0.01-100 μM) shows anti-proliferative effects on parental and CB-5083 resistant HCT116 cell lines that harbor a new p97 double mutation (D649A/T688A).
?UPCDC-30245 (4 μm; 2, 6, 10, 18, 24 hours; functional enrichment analysis) is not linked to pathways typically impacted by p97 inhibition, such as protein processing in the ER, UPR, and asparagine N-linked glycosylation.

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