SNU216/SNU216/SNU216/胃癌细胞

SNU216/SNU216细胞系/SNU216细胞株/SNU216胃癌细胞

Cell line name SNU-216

Synonyms SNU216; NCI-SNU-216

Accession CVCL_3946

Resource Identification Initiative To cite this cell line use: SNU-216 (RRID:CVCL_3946)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: Seoul National University (SNU) cell line collection.

Population: Korean.

Doubling time: 36 hours (PubMed=29435981).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.

Sequence variations

Mutation; HGNC; 11998; TP53; Simple; p.Val216Met (c.646G>A); ClinVar=VCV000182965; Zygosity=Homozygous (PubMed=9033653; DepMap=ACH-000466).

HLA typing Source: PubMed=25960936

Class I

HLA-A A*24:02,24:02

HLA-B B*51:01,52:01

HLA-C C*12:02,12:02

Class II

HLA-DR DRB1*15:02,15:02

 

Source: PubMed=26589293

Class I

HLA-A A*24:02,24:02

HLA-B B*52:01,52:01

HLA-C C*12:02,12:02

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 2.54

Native American 0

East Asian, North 69.93

East Asian, South 26.25

South Asian 0

European, North 0

European, South 1.27

Disease Gastric tubular adenocarcinoma (NCIt: C5473)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Sex of cell Female

Age at sampling 46Y

Category Cancer cell line

STR profile Source(s): KCLB=00216; PubMed=25877200

 

Markers:

Amelogenin X

CSF1PO 12

D3S1358 17

D5S818 11

D7S820 8,10

D8S1179 13,16

D13S317 9

D16S539 10,13

D18S51 16

D21S11 30,33.2

FGA 21

Penta D 9,13

Penta E 5

TH01 7

TPOX 9

vWA 14,20

 

Run an STR similarity search on this cell line

Publications

PubMed=9033653; DOI=10.1002/(SICI)1097-0215(19970207)70:4<443::AID-IJC12>3.0.CO;2-G

Park J.-G., Yang H.-K., Kim W.-H., Chung J.-K., Kang M.-S., Lee J.-H., Oh J.H., Park H.-S., Yeo K.-S., Kang S.H., Song S.-Y., Kang Y.K., Bang Y.-J., Kim Y.I., Kim J.-P.

Establishment and characterization of human gastric carcinoma cell lines.

Int. J. Cancer 70:443-449(1997)

 

PubMed=15723654; DOI=10.1111/j.1349-7006.2005.00016.x; PMCID=PMC11160020

Takada H., Imoto I., Tsuda H., Sonoda I., Ichikura T., Mochizuki H., Okanoue T., Inazawa J.

Screening of DNA copy-number aberrations in gastric cancer cell lines by array-based comparative genomic hybridization.

Cancer Sci. 96:100-110(2005)

 

PubMed=19956504; DOI=10.4143/crt.2005.37.1.1; PMCID=PMC2785416

Ku J.-L., Park J.-G.

Biology of SNU cell lines.

Cancer Res. Treat. 37:1-19(2005)

 

PubMed=22460905; DOI=10.1038/nature11003; PMCID=PMC3320027

Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.

Nature 483:603-607(2012)

 

PubMed=24807215; DOI=10.1038/ncomms4830; PMCID=PMC4024760

Liu J.-F., McCleland M.L., Stawiski E.W., Gnad F., Mayba O., Haverty P.M., Durinck S., Chen Y.-J., Klijn C., Jhunjhunwala S., Lawrence M., Liu H.-B., Wan Y.-N., Chopra V.S., Yaylaoglu M.B., Yuan W.-L., Ha C., Gilbert H.N., Reeder J., Pau G., Stinson J., Stern H.M., Manning G., Wu T.D., Neve R.M., de Sauvage F.J., Modrusan Z., Seshagiri S., Firestein R., Zhang Z.-M.

Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer.

Nat. Commun. 5:3830.1-3830.8(2014)

 

PubMed=25343454; DOI=10.1371/journal.pone.0111146; PMCID=PMC4208810

Choong M.-L., Tan S.-H., Tan T.-Z., Manesh S., Ngo A., Yong J.W.-Y., Yang H.H., Lee M.A.

Molecular integrative clustering of Asian gastric cell lines revealed two distinct chemosensitivity clusters.

PLoS ONE 9:E111146-E111146(2014)

 

PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981

Boegel S., Lower M., Bukur T., Sahin U., Castle J.C.

A catalog of HLA type, HLA expression, and neo-epitope candidates in human cancer cell lines.

OncoImmunology 3:e954893.1-e954893.12(2014)

 

PubMed=25485619; DOI=10.1038/nbt.3080

Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S., Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G., Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J., Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L., Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J., Settleman J., Seshagiri S., Zhang Z.-M.

A comprehensive transcriptional portrait of human cancer cell lines.

Nat. Biotechnol. 33:306-312(2015)

 

PubMed=25877200; DOI=10.1038/nature14397

Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M., Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S., Neve R.M.

A resource for cell line authentication, annotation and quality control.

Nature 520:307-311(2015)

 

PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878

Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.

TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.

Genome Med. 7:118.1-118.7(2015)

 

PubMed=29435981; DOI=10.1002/ijc.31304

Kim H.J., Kang S.K., Kwon W.S., Kim T.S., Jeong I., Jeung H.-C., Kragh M., Horak I.D., Chung H.C., Rha S.Y.

Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor.

Int. J. Cancer 143:151-159(2018)

 

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747; PMCID=PMC6445675

Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.

An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.

Cancer Res. 79:1263-1273(2019)