NAMALWA/NAMALWA/NAMALWA/人t＇s淋巴

NAMALWA/NAMALWA细胞系/NAMALWA细胞株/NAMALWA人t＇s淋巴瘤细胞人

Cell line name Namalwa

Synonyms NAMALWA; Namalwa IV; Namalva; NAMALVA; NWA; NK62a

Accession CVCL_0067

Resource Identification Initiative To cite this cell line use: Namalwa (RRID:CVCL_0067)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: MD Anderson Cell Lines Project.

Population: African; Kenyan.

Virology: Contains 2 integrated copies of EBV genome on chromosome 1.

Virology: Infected by squirrel monkey retrovirus (SMRV) (PubMed=1339415; PubMed=20454443).

Doubling time: 18 hours (PubMed=8402660); ~20-30 hours (DSMZ=ACC-24).

Microsatellite instability: Instable (MSI-low) (PubMed=10739008; PubMed=11226526; Sanger).

Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).

Omics: Array-based CGH.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: Deep proteome analysis.

Omics: Protein expression by reverse-phase protein arrays.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Omics: Virome analysis using RNAseq.

Caution: Indicated to have an additional TP53 p.Arg248Trp (c.742C>T) mutation according to PubMed=2052620, but not confirmed by other references or by CCLE and Cosmic-CLP.

Misspelling: NAMALLA; Cosmic=998717.

Cell type: B-cell; CL=CL_0000236.

PubMed=6811418; DOI=10.1016/S0171-2985(11)80031-8

Spira G., Koide N., Aman P., Ber R., Klein G.

Truncated mu chain in a Burkitt lymphoma line (P3HR-1) and its fate in various hemapoietic somatic cell hybrids.

Immunobiology 162:199-209(1982)

 

PubMed=6231253; DOI=10.1002/ijc.2910330407

Ehlin-Henriksson B., Klein G.

Distinction between Burkitt lymphoma subgroups by monoclonal antibodies: relationships between antigen expression and type of chromosomal translocation.

Int. J. Cancer 33:459-463(1984)

 

PubMed=2580922; DOI=10.1089/jir.1985.5.65

Feinstein S., Traub A., Lazar A., Mizrahi A., Teitz Y.

Studies on cell binding and internalization of human lymphoblastoid (Namalva) interferon.

J. Interferon Res. 5:65-76(1985)

 

PubMed=2985879; DOI=10.1016/0145-2126(85)90084-0

Drexler H.G., Gaedicke G., Minowada J.

Isoenzyme studies in human leukemia-lymphoma cell lines -- 1 carboxylic esterase.

Leuk. Res. 9:209-229(1985)

 

PubMed=2995175

Wurm F.M., Polastri G.D., Hilfenhaus J., Harth H., Zankl H.

Long term cultivation of Namalva cells for interferon production: stable cytogenetic markers for identification of cells in spite of drastic chromosomal variation.

Dev. Biol. Stand. 60:393-403(1985)

 

PubMed=2998993

Steel C.M., Morten J.E.N., Foster E.

The cytogenetics of human B lymphoid malignancy: studies in Burkitt's lymphoma and Epstein-Barr virus-transformed lymphoblastoid cell lines.

IARC Sci. Publ. 60:265-292(1985)

 

PubMed=3159941; DOI=10.1016/0145-2126(85)90134-1

Drexler H.G., Gaedicke G., Minowada J.

Isoenzyme studies in human leukemia-lymphoma cell lines -- III Beta-hexosaminidase (E.C. 3.2.1.30).

Leuk. Res. 9:549-559(1985)

 

PubMed=3874327; DOI=10.1016/0145-2126(85)90133-x

Drexler H.G., Gaedicke G., Minowada J.

Isoenzyme studies in human leukemia-lymphoma cells lines -- II. Acid phosphatase.

Leuk. Res. 9:537-548(1985)

 

PubMed=3997900; DOI=10.1016/S0092-1157(85)80024-x

Whitaker A.M.

The chromosomes of the Namalwa cell line.

J. Biol. Stand. 13:173-175(1985)

 

PubMed=2415623; DOI=10.4049/jimmunol.136.1.320

Goldmacher V.S., Lambert J.M., Young A.Y., Anderson J., Tinnel N.L., Kornacki M., Ritz J., Blattler W.A.

Expression of the common acute lymphoblastic leukemia antigen (CALLA) on the surface of individual cells of human lymphoblastoid lines.

J. Immunol. 136:320-325(1986)

 

PubMed=3080238

Sieverts H., Alabaster O., Goldschmidts W., Magrath I.T.

Expression of surface antigens during the cell cycle in different growth phases of American and African Burkitt's lymphoma cell lines.

Cancer Res. 46:1182-1188(1986)

 

PubMed=3026973; DOI=10.1002/ijc.2910390215

Ehlin-Henriksson B., Manneborg-Sandlund A., Klein G.

Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.

Int. J. Cancer 39:211-218(1987)

 

PubMed=2830981; DOI=10.1016/0092-8674(88)90530-2

Lawrence J.B., Villnave C.A., Singer R.H.

Sensitive, high-resolution chromatin and chromosome mapping in situ: presence and orientation of two closely integrated copies of EBV in a lymphoma line.

Cell 52:51-61(1988)

 

PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x; PMCID=PMC452998

Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.

p53 is frequently mutated in Burkitt's lymphoma cell lines.

EMBO J. 10:2879-2887(1991)

 

PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883

Gaidano G., Ballerini P., Gong J.Z., Inghirami G., Neri A., Newcomb E.W., Magrath I.T., Knowles D.M., Dalla-Favera R.

p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.

Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

 

PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289

Benjamin D., Knobloch T.J., Dayton M.A.

Human B-cell interleukin-10: B-cell lines derived from patients with acquired immunodeficiency syndrome and Burkitt's lymphoma constitutively secrete large quantities of interleukin-10.

Blood 80:1289-1298(1992)

 

PubMed=1339415; DOI=10.1002/ijc.2910520320

Middleton P.G., Miller S., Ross J.A., Steel C.M., Guy K.

Insertion of SMRV-H viral DNA at the c-myc gene locus of a BL cell line and presence in established cell lines.

Int. J. Cancer 52:451-454(1992)