RT112/RT112/RT112/人膀胱癌移行细胞

RT112/RT112细胞系/RT112细胞株/RT112人膀胱癌移行细胞

Cell line name RT-112

Synonyms RT 112; RT112

Accession CVCL_1670

Resource Identification Initiative To cite this cell line use: RT-112 (RRID:CVCL_1670)

Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).

Part of: COSMIC cell lines project.

Part of: TCGA-110-CL cell line panel.

Part of: UBC-40 urothelial bladder cancer cell line index.

Population: Caucasian.

Doubling time: 24 hours (PubMed=3708594); 25 hours (PubMed=25984343); 25.7 hours (PubMed=26055179); 21.6 +- 0.1 hours (PubMed=2144165); ~35 hours (DSMZ=ACC-418).

Microsatellite instability: Stable (MSS) (Sanger).

Omics: CNV analysis.

Omics: Deep exome analysis.

Omics: Deep quantitative proteome analysis.

Omics: DNA methylation analysis.

Omics: shRNA library screening.

Omics: SNP array analysis.

Omics: Transcriptome analysis by microarray.

Omics: Transcriptome analysis by RNAseq.

Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.

Sequence variations

Gene fusion; HGNC; 3690; FGFR3 + HGNC; 11524; TACC3; Name(s)=FGFR3-TACC3 (PubMed=25485619; PubMed=28855393).

Mutation; HGNC; 11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (PubMed=24035680; PubMed=31068700).

Mutation; HGNC; 11998; TP53; Simple; p.Ser183Ter (c.548C>G); ClinVar=VCV000634701; Zygosity=Heterozygous (Cosmic-CLP=909704; DepMap=ACH-000473).

Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (Cosmic-CLP=909704; DepMap=ACH-000473).

HLA typing Source: PubMed=26589293

Class I

HLA-A A*26:01,26:01

HLA-B B*08:01,27:05

HLA-C C*01:02,01:02

Class II

HLA-DR DRB1*03:17,15:01

Genome ancestry Source: PubMed=30894373

 

Origin % genome

African 0

Native American 0

East Asian, North 1.6

East Asian, South 0

South Asian 0

European, North 65.6

European, South 32.8

Disease Bladder carcinoma (NCIt: C4912)

Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)

Hierarchy Children:

CVCL_C7JU (RT112 CP1.5) CVCL_2714 (RT112/84) CVCL_6215 (RT112/D21)

CVCL_B7BP (RT112-CP) CVCL_RR17 (RT112rCDDP1000) CVCL_RR18 (RT112rGEMCI20)

Sex of cell Female

Age at sampling Age unspecified

Category Cancer cell line

STR profile Source(s): CLS=300324; Cosmic-CLP=909704; DSMZ=ACC-418; PubMed=11416159; PubMed=25877200; PubMed=27270441

 

Markers:

Amelogenin X

CSF1PO 10 (PubMed=25877200)

10,11 (CLS=300324; Cosmic-CLP=909704; DSMZ=ACC-418; PubMed=27270441)

D2S1338 17,24

D3S1358 15

D5S818 10,13

D7S820 11,12

D8S1179 13,15

D13S317 13,14

D16S539 11,13

D18S51 15 (CLS=300324)

15,17 (DSMZ=ACC-418; PubMed=25877200)

D19S433 13,15

D21S11 27,30

FGA 23 (CLS=300324)

23,25 (DSMZ=ACC-418; PubMed=25877200)

Penta D 10 (DSMZ=ACC-418; PubMed=25877200)

10,11 (CLS=300324)

Penta E 12,16

TH01 7

TPOX 8,11

vWA 14,17

 

Run an STR similarity search on this cell line

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