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- 2025年12月05日
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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Pure form: -20°C, 3 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
DHLA
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
462-20-4
- 规格：
10 mM * 1 mL/25 mg/50 mg/100 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥385.0 |
|---|---|---|---|
| 规格： | 25 mg | 产品价格： | ￥350.0 |
| 规格： | 50 mg | 产品价格： | ￥610.0 |
| 规格： | 100 mg | 产品价格： | ￥980.0 |
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Dihydrolipoic Acid
CAS No. : 462-20-4
MCE 国际站：Dihydrolipoic Acid
产品活性：Dihydrolipoic Acid (DHLA) 是一种效果极好的抗氧化剂，能够清除几乎所有以氧为中心的自由基。Dihydrolipoic Acid 在多种疾病中表现出抗炎特性。Dihydrolipoic Acid 通过 ERK/Nrf2/HO-1/ROS/NLRP3 通路在 LPS 诱导的疾病行为大鼠中发挥预防作用。Dihydrolipoic Acid 可用于抑郁症的研究。
研究领域：Immunology/Inflammation | NF-κB | Metabolic Enzyme/Protease
In Vitro: Dihydrolipoic Acid is an antioxidant. DHLA is capable of scavenging ?OH radicals and scavenging superoxide radical anions with a rate constant of 3.3×105 M-1 s-1. Dihydrolipoic Acid is an excellent antioxidant, and that is very important because O2?- is a relatively mild oxidant that is therefore much more selective and can be useful to discriminate between the antioxidant capacities of different substrates.
In Vivo: Dihydrolipoic Acid (DHLA) treatment exerts preventive effects in LPS-induced sickness behavior rats. Dihydrolipoic Acid increases the expression of ERK, Nrf2, and HO-1 but decreases the ROS generation levels and reduces the expression of NLRP3, caspase-1, and IL-1β in LPS-induced sickness behavior rats. Dihydrolipoic Acid is a reduced form of α-lipoic acid (LA) that can decrease oxidative stress and act as a strong antioxidant. Dihydrolipoic Acid treatment reverses the LPS-induced sickness behavior.
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文献和实验巯（SH）基 SH－group，sulfhydryl group
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