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Terreic acid
CAS No. : 121-40-4
MCE 国际站：Terreic acid
产品活性：Terreic acid 是一种醌环氧化物抗生素 (antibiotic)，是一种有效的 Btk 抑制剂。 Terreic acid 阻断 PKC 和 Btk 的 PH结构域之间的相互作用。 Terreic acid 作用于HMC-1 人肥大细胞裂解物，抑制 GST-BtkPH 与 PKC 结合，IC50 约为 100 μM。
研究领域：Protein Tyrosine Kinase/RTK | Anti-infection
作用靶点：Btk | Antibiotic
In Vitro: Terreic acid inhibits the association of Btk with PKCβII in mouse mast cells at lower concentrations (IC50 of ≈30 μM). Terreic acid inhibits the catalytic activity of Btk but not PKC.
Terreic acid (pretreatment for 30 min before stimulation by antigen for 3 min) inhibits both the basal and activation levels of Btk autophosphorylating activity with IC50s of 10 μM and 3 μM, respectively.
Terreic acid inhibits the autophosphorylating activity of Btk purified partially from recombinant baculovirus-infected Sf9 insect cells in a dose-dependent manner.
In Vivo: Terreic acid inhibits the late-phase response of in vivo allergic cutaneous reactions.
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文献和实验kDa protein consisting of 121 amino acid residues is produced as a homodimer. VEGF is a polypeptide growth factor and a member of the platelet-derived growth factor family. It is a specific mitogen for vascular endothelial cells and a strong angiogenic
nucleic acid)/DNA hybrid duplexes and DNA/DNA duplexes. Nucleic Acids Symp Ser 1999;(42):93-4. 5. Sosnowski RG, Tu E, Butler WF, et al. Rapid determination of single base mismatch mutations in DNA hybrids by direct electric field control. Proc Natl
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