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- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
4°C, sealed storage, away from moisture and light
- 英文名：
CID-53361951; ML-270
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1970.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1800.0 |
| 规格： | 10 mg | 产品价格： | ￥2800.0 |
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VU0359595
CAS No. : 1246303-14-9
MCE 国际站：VU0359595
产品活性：VU0359595 (CID-53361951; ML-270) 是一种选择性磷脂酶 D1 (PLD1) 抑制剂，IC50 值为 3.7 nM。VU0359595 对 PLD1 的选择性比 PLD2 (IC50=6.4 μM) 高 1700 倍以上。VU0359595 可用于癌症、糖尿病、神经退行性疾病和炎性疾病等疾病研究。
研究领域：Metabolic Enzyme/Protease | Anti-infection
作用靶点：Phospholipase | Fungal
In Vitro: VU0359595 (5, 50, 500, 5000 nM) inhibits basal and FCS/IGF-1 stimulated proliferation of astroglial cells.
VU0359595 (5, 50, 500 nM; 30 min) does not affect basal PLD activity in astrocytes but reduces mitogen-stimulated PLD activity in a concentration-dependent manner.
VU0359595 (0.15 μM; 1 h before high glucose treatment and 4 h during high glucose treatment) partially reduces the increase [3H]-phosphatidylethanol (PEth) generation induced by high glucose (33 mM) in retinal pigment epithelium (RPE) cells.
VU0359595 (5 μM; 1 h prior to LPS treatment) modulates the autophagic process of LPS-induced (10 μg/ml; 24 h) RPE cells.
VU0359595 (2 nM; pretreatment 30 min) blocks the increase of A. fumigatus internalization induced by 50 ng/ml gliotoxin in A549 cells.
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Becker, D. and Lrz H. (2006 ) Genetic transformation ofbarley ( H o rd eu m vu lg a re L. ) via infection of androgenetic pollen cultures with A g ro b a cteriu m tu m efa cien s.P la n t B io tech n o l. /. 4 , 251-261. 14.
Chromosome Conformation Capture Carbon Copy Technology
analysis of cis ? and trans ?chromatin interactions in mammalian cells. Curr. Protoc. Mol. Biol. 80:21.14.1?21.14.13. © 2007 by John Wiley & Sons, Inc. Keywords: chromatin structure; epigenetic regulation; genomics; systems/network
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