Bezisterim,1001100-69-1

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。

Bezisterim

CAS No. : 1001100-69-1

MCE 国际站：Bezisterim

产品活性：Bezisterim (HE 3286; NE-3107) 是天然抗炎类固醇 β-AET 的合成衍生物。Bezisterim 是具有口服活性的 NF-κB 部分抑制剂。Bezisterim 降低了促炎信号，包括 IL-6 和基质金属肽酶 3。Bezisterim 可自由穿过小鼠血脑屏障。Bezisterim 可用于溃疡性结肠炎、关节炎、实验性自身免疫性脑脊髓炎的研究。Bezisterim 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

研究领域：NF-κB

作用靶点：NF-κB

In Vitro: Bezisterim attenuates NF-κB phosphorylation, but not influences IκB phosphorylation of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages.
Bezisterim (100 nM, overnight) partially blocks the activation of IKK, JNK, p38, and ERK of LPS-induces (100 ng/mL; 0-2 hours) murine macrophages.

In Vivo: Bezisterim (25-50 mg/kg; oral gavage; daily for 22-49 days) reduces joint inflammation, synovial proliferation, and erosion of DBA/1 Lac male collagen-induced arthritis mice .
Bezisterim (40 mg/kg; intraperitoneal injection; daily for 40 days) suppresses inflammation, reduces demyelination and axonal loss, and promotes RGC survival during experimental optic neuritis of experimental autoimmune encephalomyelitis mice.
Bezisterim (80?mg/kg; 0-24h) freely penetrates the BBB in male CD-1 mice.
Bezisterim (40 mg/kg; gavage; twice-daily for 4 days) increases the numbers of tyrosine hydroxylase-positive cells and decreases the numbers of damaged neurons in Parkinson's disease mice.

相关产品：Drug Repurposing Compound Library Plus  |  Clinical Compound Library Plus  |  Bioactive Compound Library Plus  |  Immunology/Inflammation Compound Library  |  NF-κB Signaling Compound Library  |  Stem Cell Signaling Compound Library  |  Clinical Compound Library  |  CNS-Penetrant Compound Library  |  Anti-Aging Compound Library  |  Drug Repurposing Compound Library  |  Antioxidant Compound Library  |  Differentiation Inducing Compound Library  |  Lipid Compound Library  |  Oxygen Sensing Compound Library  |  Pyroptosis Compound Library  |  Orally Active Compound Library  |  Anti-Breast Cancer Compound Library  |  Anti-Pancreatic Cancer Compound Library  |  Anti-Blood Cancer Compound Library  |  Anti-Cancer Metabolism Compound Library  |  Anti-Obesity Compound Library  |  Transcription Factor-Targeted Library  |  Anti-Liver Cancer Compound Library   |  Antidepressant Compound Library  |  Anti-Prostate Cancer Compound Library  |  Cancer Stem Cells Compound Library  |  Pain-Related Compound Library  |  Phorbol 12-myristate 13-acetate  |  Bortezomib  |  BAY 11-7082  |  TAK-243  |  JSH-23  |  Sulfasalazine  |  Shikonin  |  Pyrrolidinedithiocarbamate ammonium  |  Triptolide  |  Aspirin  |  Dihydroartemisinin  |  Baicalin  |  Parthenolide  |  BAY 11-7085  |  5-Aminosalicylic Acid  |  CBL0137 hydrochloride  |  Rocaglamide  |  Betulinic acid  |  Isoginkgetin  |  SN50  |  SC75741  |  QNZ  |  Andrographolide  |  Astaxanthin  |  Hyperoside  |  20(S)-Ginsenoside Rg3  |  B022  |  Lidocaine  |  Withaferin A  |  (-)-DHMEQ

热门产品线：重组蛋白  |  化合物库  |  天然产物  |  荧光染料  |  PROTAC  |  同位素标记物

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Dye Reagents  |  PROTAC  |  Isotope-Labeled Compounds