Nemorosone,351416-47-2

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Nemorosone

CAS No. : 351416-47-2

MCE 国际站：Nemorosone

产品活性：Nemorosone 是 Clusia rosea 树脂的主要成分。Nemorosone 对癌细胞有抗增殖作用。Nemorosone 诱导 HT-29 和 LoVo 细胞凋亡 (apoptosis)。

研究领域：Apoptosis

作用靶点：Apoptosis

In Vitro: Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC₅₀s of 25.7-27.1 μM, 22.8-64.3 μM, respectively.
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells.
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines.

In Vivo: Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts.

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