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APC Anti-Human CD62P (AK4) APC

-65164
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  • ¥1100 - 2740
  • Proteintech已认证
  • APC-65164
  • 2025年10月13日
  • FC
  • Mouse
  • Human, Non-human primates
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 免疫原

      None

    • 亚型

      IgG1, kappa

    • 保存条件

      Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

    • 克隆性

      Monoclonal

    • 标记物

      APC Fluorescent Dye

    • 适应物种

      Human, Non-human primates

    • 保质期

      详见产品包装

    • 库存

      充足

    • 宿主

      Mouse

    • 应用范围

      FC

    • 靶点

      CD62P

    • 抗体英文名

      APC Anti-Human CD62P (AK4)

    • 抗体名

      APC Anti-Human CD62P (AK4)

    • 规格

      25tests/100tests

    规格:25tests产品价格:¥1100.0
    规格:100tests产品价格:¥2740.0

    经过测试的应用

    Positive FC detected inhuman peripheral blood platelets

    推荐稀释比

    应用推荐稀释比
    Flow Cytometry (FC)FC : 5 ul per 10^6 cells in 100 μl suspension
    This reagent has been pre-titrated and tested for flow cytometric analysis. The suggested use of this reagent is 5 ul per 10^6 cells in a 100 µl suspension or 5 ul per 100 µl of whole blood.
    Sample-dependent, Check data in validation data gallery.

    产品信息

    APC-65164 targets CD62P in FC applications and shows reactivity with Human, Non-human primates samples.

    经测试应用 FC
    经测试反应性 Human, Non-human primates
    免疫原

    fusion protein

    宿主/亚型 Mouse / IgG1, kappa
    抗体类别 Monoclonal
    产品类型 Antibody
    全称 selectin P (granule membrane protein 140kDa, antigen CD62)
    别名 AK4, CD62, CD62P, FLJ45155, GMP 140, GMP140, GMRP, Granule membrane protein 140, GRMP, LECAM3, P selectin, PADGEM, PSEL, SELP
    计算分子量 830 aa, 91 kDa
    GenBank蛋白编号BC028067
    基因名称 CD62P
    Gene ID (NCBI) 6403
    RRIDAB_2883036
    偶联类型 APC Fluorescent Dye
    最大激发/发射波长650 nm / 660 nm
    形式Liquid
    纯化方式The purified antibody is conjugated with allophycocyanin (APC) under optimum conditions. The conjugate is purified by size-exclusion chromatography.
    UNIPROT IDP16109
    储存缓冲液 PBS with 0.09% sodium azide and 0.5% BSA, pH 7.3.
    储存条件Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.

    背景介绍

    P-selectin, also known as GMP140 or CD62P, is a transmembrane glycoprotein that mediates the interaction of activated endothelial cells or platelets with leukocytes. It is an adhesion molecule involved in the pathogenesis of inflammation, thrombosis, and oncogenesis. P-selectin is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface.

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    图标文献和实验
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      结直肠癌 (CRC) 是胃肠道中常见的恶性肿瘤,其形成也是一个逐步发展的过程。前期研究数据表明,大多数结直肠癌起始于异常的腺窝,后逐渐演变成息肉,最终发展为结肠直肠癌,整个过程可长达 5 - 15 年。在内在分子机制层面,大多数结直肠癌是通过 WNT 通路的永久激活而启动的,而这种激活通常是发生在肠道干细胞中肿瘤抑制基因 APC 的突变之后。 APC 的突变可诱导肠内细胞增殖增加,防止细胞死亡并阻断分化,所有这些特征均可能有助于提高 APC 突变细胞的相对适应度,APC 突变的肠道干细胞及其后

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    ¥1100 - 2740