- ￥1350 - 3000
- Proteintech
- 18009-1-AP
- 2025年10月13日
- WB, ELISA
- Rabbit
- human, mouse, rat
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- 详细信息
- 文献和实验
- 技术资料
- 免疫原：
Recombinant human NP protein
- 亚型：
IgG
- 保存条件：
Store at -20°C. Stable for one year after shipment.
- 克隆性：
Polyclonal
- 标记物：
Unconjugated
- 适应物种：
human, mouse, rat
- 保质期：
详见产品包装
- 库存：
充足
- 宿主：
Rabbit
- 应用范围：
WB, ELISA
- 靶点：
Nucleoside phosphorylase
- 抗体英文名：
Nucleoside phosphorylase Polyclonal antibody
- 抗体名：
Nucleoside phosphorylase Polyclonal antibody
- 规格：
50ul/100ul/150ul
| 规格： | 50ul | 产品价格： | ￥1350.0 |
|---|---|---|---|
| 规格： | 100ul | 产品价格： | ￥2200.0 |
| 规格： | 150ul | 产品价格： | ￥3000.0 |
经过测试的应用
| Positive WB detected in | Jurkat cells, U-937 cells, K-562 cells, Raji cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:1000-1:4000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
18009-1-AP targets Nucleoside phosphorylase in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.
| 经测试应用 | WB, ELISA |
| 文献引用应用 | WB, IF |
| 经测试反应性 | human, mouse, rat |
| 文献引用反应性 | human, mouse, rat, canine |
| 免疫原 |
CatNo: Ag12507 Product name: Recombinant human NP protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-289 aa of BC106074 Sequence: MENGYTYEDYKNTAEWLLSHTKHRPQVAIICGSGLGGLTDKLTQAQIFDYGEIPNFPRSTVPGHAGRLVFGFLNGRACVMMQGRFHMYEGYPLWKVTFPVRVFHLLGVDTLVVTNAAGGLNPKFEVGDIMLIRDHINLPGFSGQNPLRGPNDERFGDRFPAMSDAYDRTMRQRALSTWKQMGEQRELQEGTYVMVAGPSFETVAECRVLQKLGADAVGMSTVPEVIVARHCGLRVFGFSLITNKVIMDYESLEKANHEEVLAAGKQAAQKLEQFVSILMASIPLPDKAS |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Polyclonal |
| 产品类型 | Antibody |
| 全称 | nucleoside phosphorylase |
| 别名 | PNP, EC:2.4.2.1, Inosine phosphorylase, Inosine-guanosine phosphorylase, PRO1837 |
| 计算分子量 | 289 aa, 32 kDa |
| 观测分子量 | 32 kDa |
| GenBank蛋白编号 | BC106074 |
| 基因名称 | Purine nucleoside phosphorylase |
| Gene ID (NCBI) | 4860 |
| RRID | AB_2034971 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Antigen affinity purification |
| UNIPROT ID | P00491 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
Purine nucleoside phosphorylases (PNP) is a ubiquitous enzyme of purine metabolism that functions in the salvage pathway, including even those of protozoan parasites, thus enabling the cells to utilize purine bases recovered from metabolized purine ribo- and deoxyribonucleosides to synthesize purine nucleotides (PMID: 11337031, 23332162). PNP deficiency in humans leads to an impairment of T-cell function, usually with no apparent effects on B-cell function. hPNP is widely distributed in various tissues and cells of the human body, with the highest activity in kidney, peripheral lymphocytes and granulocytes (PMID: 38701712).
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文献和实验| Species | Application | Title |
|---|---|---|
| human | WB | J Hazard Mater Integrative proteomics and metabolomics approach to elucidate metabolic dysfunction induced by silica nanoparticles in hepatocytes.Authors - Ye Zhu |
J Biol Chem Patient-derived organotypic tissue cultures as a platform to evaluate metabolic reprogramming in breast cancer patientsAuthors - Teresa W -M Fan | ||
| canine | WB | Biologicals CDC20 is a potential target gene to inhibit the tumorigenesis of MDCK cellsAuthors - Zhenbin Liu |
| rat | WB,IF | Int Immunopharmacol Spermidine attenuates monocrotaline-induced pulmonary arterial hypertension in rats by inhibiting purine metabolism and polyamine synthesis-associated vascular remodelingAuthors - Yu-Jing Chen |
| mouse,human | WB | Cell De novo and salvage purine synthesis pathways across tissues and tumorsAuthors - Diem H Tran |
| mouse,human | WB | J Ethnopharmacol Diosmetin-7-O-β-D-glucopyranoside from Pogostemonis Herba alleviated SARS-CoV-2-induced pneumonia by reshaping macrophage polarization and limiting viral replicationAuthors - Yun-Lu Xu |
核苷磷酸化酶 nucleoside phosphorylase
以次黄苷 磷酸次黄嘌呤 核糖 -1-磷酸的方式，参与将核苷加磷酸分解成五碳糖磷酸反应的酶之总称。已知有几种对底物的特异性不同，如嘌呤核苷磷酸化酶（ EC2． 4． 2． 1）对鸟苷、脱氧鸟苷、次黄苷、脱氧次黄苷具有作用，它存在于脾、肺、肝、心肌、红血球、酵母中，小肠和血液中也有少量存在。另外已知嘧啶核苷磷酸化酶是对尿苷和胸腺苷分别具有特异性的酶。推测主要是分解核苷或具有供给合成其它核苷所需的核糖磷酸的作用。
Real-Time RT-PCR (Taqman) of Tumor mRNA to Predict Sensitivity of Specimens to 5-Fluorouracil
obtained cancer specimens and expression of thymidylate synthetase (TS), dihydropyrimidine dehydrogenase (DPD), thymidine phosphorylase (TP), uridine phosphorylase (UP), es-nucleoside transporter (NT), and E2F1 are detected by real-time reverse
Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare disease characterized by severe gastro-intestinal (GI) dysmotility caused by mutations in the thymidine phosphorylase gene. Thymidine phosphorylase (TP) is involved
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