GluR2 多克隆抗体

免疫组织化学（IHC）已验证样本:Human liver cancer,Human colon cancer

IHC 1:100-1:300

Polyclonal

IgG

Synthetic peptide of human GRIA2

GRIA2

AMPA 2;AMPA selective glutamate receptor 2;AMPA-selective glutamate receptor 2;AMPA2;GluA2;GLUR 2;GLUR B;GluR K2;GluR-2;GluR-B;GluR-K2;GLUR2;GLURB;Glutamate receptor 2;Glutamate receptor ionotropic AMPA 2;Glutamate receptor ionotropic;Gria2;GRIA2;HBGR2抗体

P42262

Cell membrane. Endoplasmic reticulum membrane. Cell junction>synapse>postsynaptic cell membrane. Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

0.4 mg/mL

在-20℃下储存有效期为12个月。 避免冻融循环。

PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Affinity purification

Cancer; Neuroscience

Unconjugated

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene.