- 询价
- Cell Signaling Technology
- 2806
- USA
- 2025年10月30日
- W, IP
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
WAVE-3 Antibody
- 抗原：
synthetic peptide corresponding to the central sequence of human WAVE-3
- 应用范围：
W, IP
- 宿主：
Rabbit
- 保质期：
详见说明书
- 库存：
大量
- 适应物种：
H,M,R,Mk
- 供应商：
CST
- 级别：
详见MSDS文件
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H M R Mk | Endogenous | 65-70 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | WAVE-3 Antibody detects endogenous levels of total WAVE-3 protein. The antibody does not cross-react with WAVE-1 or WAVE-2. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the central sequence of human WAVE-3. Antibodies are purified using protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from various cell types using WAVE-3 Antibody. IP
Immunoprecipitation of WAVE-3 from SH-SY5Y extracts using WAVE-3 Antibody (lane 2). Lane 1 is 5% input. Western blot detection was performed using the same antibody. |
| Background | Wiskott-Aldrich syndrome proteins (WASPs) mediate actin dynamics by activating the Arp2/3 actin nucleation complex in response to activated Rho family GTPases. In mammals, five WASP family members have been described. Hematopoietic WASP and ubiquitously expressed N-WASP are autoinhibited in unstimulated cells. Upon stimulation they are activated by cdc42, which relieves the autoinhibition in conjunction with phosphatidyl inositol 4,5-bisphosphate. Three WAVE (Wasf, SCAR) family proteins are similar in sequence to WASP and N-WASP but lack the WASP/N-WASP autoinhibition domains and are indirectly activated by Rac (reviewed in 1). Both WASP and WAVE functions appear to be essential, as knockout of either N-WASP or Scar-2 in mice results in cardiac and neuronal defects and embryonic lethality (2,3). Loss of WASP results in immune system defects and fewer immune cells (4). WAVE-2 (WASF2) is widely distributed, while WAVE-1 and WAVE-3 are strongly expressed in brain (5). WAVE-3 may act as a tumor suppressor in neuroblastoma, a childhood disease of the sympathetic nervous system (6). Increased expression of WAVE-3 is seen in breast cancer, and studies in breast adenocarcinoma cells indicate that WAVE-3 regulates breast cancer progression, invasion and metastasis through the p38 mitogen-activated protein kinase (MAPK) pathway (7,8).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验纤毛波 metachronal wave of cilia 靠纤毛的连续性运动所产生的纤毛的波，称纤毛波。一般纤毛排成列或排列在面上时，邻接的纤毛按一定的方向保持一定的位差而运动。因此如把纤毛列或纤毛面作为整体观察时，可以看到波按一定方向依次传动。纤毛波之传动方向和有效摆动方向之间的关系，视动物种类和组织而定。据此可将纤毛波分为如下表所示的 4类型。关于纤毛波之形成机理，根据对瓣鳃纲鳃的纤毛和草履虫的研究，认为系纤毛间的力学干扰所致。但也有人认为，栉水母之栉板带上的纤毛波
从头皮上诱导记录下来的人或动物大脑所产生的电位变化的记录图，称为脑电图（ EEG），由电位差所引起的电流称为脑电流。“脑波”一词主要与后者同义，但有时也指前者。从头皮上诱导的电位充其量不过几 10微伏，经放大后才能记录。其波形如嗓音呈不规则的状态，但在 10赫芝左右的稍规则的成分（α波）中混有 17— 50赫芝不规则的振幅小的成分（β波）。在感觉刺激或精神活动如心算时，α波消失。在睡眠和麻醉等情况下，脑波的变化很大，出现更慢的δ波。在睡眠或癫痫
足波 pedal wave 系指腹足类在匍伏时，其足的下面相继起伏的一种收缩波（蜗牛为 10条左右）。将动物放在玻璃板上爬行，透过玻璃板即能观察到。这是肌肉运动的一种特殊形式，推动动物体前进的机制与蠕动运动相近似。实际上足波是足的下面，紧贴物体表面的静止部分和主要靠腹背走向的肌纤维之收缩而可提举的部分。形成交错的横纹。可分为向前方运动的顺行型（ direct type）（例：蜗牛）和向后方运动的逆行型（ retrograde type）（例：海兔）。前进是由于可提举的部分不断向前
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