- 询价
- Cell Signaling Technology
- 2645
- USA
- 2025年08月27日
- W, IP
- Rabbit
- H,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
Trf2 Antibody
- 抗原：
synthetic peptide correspoding to residues near the carboxy terminus of human Trf2
- 应用范围：
W, IP
- 宿主：
Rabbit
- 库存：
大量
- 级别：
详见MSDS文件
- 供应商：
CST
- 适应物种：
H,Mk
- 保质期：
详见说明书
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IP=Immunoprecipitation
Reactivity Key: H=Human Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IP | H Mk | Endogenous | 65 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Trf2 Antibody detects endogenous levels of Trf2 protein. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide correspoding to residues near the carboxy terminus of human Trf2. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from COS-7, HT29 and RD-ES cells, using Trf2 Antibody. IP
Western blot analysis of whole cell lysate (lane 1) and Trf2 immunoprecipitated from RD-ES cells (lane 2), using Trf2 Antibody. |
| Background | Telomeres, the linear ends of chromosomes, are organized into T-loops to prevent them from being recognized by the cell as DNA double stranded breaks (DSBs) (1). The telomeric repeat binding factor proteins, Trf1 and Trf2, bind to double-stranded telomeres, allowing formation of T-loops (2). A large number of proteins involved in the DNA damage response are found present within telomeres physically associated with Trf2 (3). Interestingly, Trf2 can be observed to transiently localize to DNA damage-induced DSBs, but overexpression of Trf2 prevents ATM-dependent signaling (4). Phosphorylation of Trf2 at Ser323 has been reported in vivo, but no upstream kinase or role has been established for this phosphorylation site (5).
|
| Application References | Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验Generation of Antibody Molecules Through Antibody Engineering
been overcome to a large extent using genetic-engineering techniques to produce chimeric mouse/human and completely human antibodies. Such an approach is particularly suitable because of the domain structure of the antibody molecule ( 2 ), where functional
The importance of antibody molecules was first recognized in the 1890s, when it was shown that immunity to tetanus and diphtheria was caused by antibodies against the bacterial exotoxins (1 ). Around the same time, it was shown that antisera
General comments: Antibodies, like most proteins, do not like to be freeze-thawed. Avoid repetitive freezing of your solution. The best way to store your antibody is to keep a high protein concentration (>1 mg/ml), add some protease
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