- 询价
- Cell Signaling Technology
- 9591
- USA
- 2025年11月06日
- W
- Rabbit
- H,M,R
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- 详细信息
- 技术资料
- 抗体英文名：
Phospho-MSK1 (Ser376) Antibody
- 抗原：
synthetic phosphopeptide corresponding to residues surrounding Ser376 of human MSK1
- 应用范围：
W
- 宿主：
Rabbit
- 保质期：
详见说明书
- 适应物种：
H,M,R
- 库存：
大量
- 级别：
详见MSDS文件
- 供应商：
CST
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting
Reactivity Key: H=Human M=Mouse R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W | H M R | Endogenous | 90 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Phospho-MSK1 (Ser376) Antibody detects endogenous levels of MSK1 only when phosphorylated at Ser376. The antibody does not recognize MSK1 phosphorylated at other sites, nor does it recognize phosphorylated RSK1, RSK2 or RSK3. Thisantibody may cross react with MSK2. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser376 of human MSK1. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from RSK1, RSK2, RSK3 or MSK1 transfected 293 cells, untreated or TPA-treated (200 nM), using Phospho-MSK1 (Ser376) Antibody. Western Blotting
Western blot analysis of extracts from 293 cells, untreated, TPA-treated or UV-treated, using Phospho-MSK1 (Ser376) Antibody. Western Blotting
Western blot analysis of extracts from 293 cells transfected with MSK1 or various mutants of MSK1, then treated with TPA (200 nM), and analyzed using Phospho-MSK1 (Ser376) Antibody. |
| Background | MSK1, a mitogen and stress activated protein kinase, is activated by Erk as well as p38 MAPK in response to growth factors and cellular stress, respectively (1). MSK1 resembles RSK because it has two kinase domains connected by a regulatory linker region (2). Phosphorylation of RSK1 at Ser364 and Ser381 is critical for RSK1 activity (3). These sites are analogous to Ser360 and Ser376 of MSK1, which may be important for MSK1 activity as well. |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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