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- InCELL Hunter™
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- 96-0048E15CP0L
- 2025年06月24日
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1,000 dp (10 x 96-well)
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文献和实验Cell-Based Assays to Probe the ERK MAP Kinase Pathway in Endothelial Cells
to label phosphorylated target proteins; images were captured with the INCell Analyzer 3000 and analyzed with the INCell Analyzer 3000 software. The first of these two assays monitors phosphorylation of ERK1/2, while the second assay monitors activation
, it is necessary to comprehend the specificity profile of a given kinase inhibitor. Capture Compound Mass Spectrometry (CCMS) (Koster et al., Assay Drug. Dev. Technol. 5:381–390, 2007) addresses the need for a tool to physically isolate and reliably profile
Identification of a Mutant Kinase/ATP Analog Pair
a "pocket" in the ATP-binding site that allows the mutant kinase, but not the wild-type kinase or other cellular kinases, to utilize analogs of ATP with bulky substituents synthesized onto the N6 position. Kinase reactions performed with a mutated kinase
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