- 询价
- Cell Signaling Technology
- 2452
- USA
- 2025年08月23日
- W, IF-IC
- Rabbit
- H,M,R,Mk
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- 详细信息
- 文献和实验
- 技术资料
- 抗体英文名：
APP Antibody
- 抗原：
synthetic peptide corresponding to residues surrounding Thr668 of human APP695
- 应用范围：
W, IF-IC
- 宿主：
Rabbit
- 适应物种：
H,M,R,Mk
- 供应商：
CST
- 保质期：
详见说明书
- 级别：
详见MSDS文件
- 库存：
大量
- 是否单克隆：
2
- 保存条件：
-20°c
- 规格：
100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key: H=Human M=Mouse R=Rat Mk=Monkey
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Source |
|---|---|---|---|---|
| W IF-IC | H M R Mk | Endogenous | 100 to 140 | Rabbit |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | APP Antibody detects endogenous levels of several isoforms of both mature and immature amyloid beta (A4) precursor protein, including APP695, APP770 and APP751. |
| Source / Purification | Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr668 of human APP695. Antibodies are purified by protein A and peptide affinity chromatography. Western Blotting
Western blot analysis of extracts from HeLa (human), 3T3L1 (mouse) or C6 (rat) cells, untreated or nocodazole-treated (1 µg/ml, 16-18 hours), using APP Antibody. IF-IC
Confocal microscopic images of SH-SY5Y cells showing cytoplasmic and ER stain with APP Antibody (A, red) compared to an isotype control (B). Blue pseudocolor = DRAQ5ä (fluorescent DNA dye). |
| Background | Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain (Aβ), which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (AD) (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (at a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell cycle-dependent and peaks during G2/M phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).
|
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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文献和实验APP-Based Transgenic Models: The APP23 Model
up to date are partial, but nevertheless, essential in further unraveling the nature, and spatial and temporal development of the complex molecular pathology underlying this condition. One of the more recent transgenic attempts to model AD is the APP23
都说手机、平板影响睡眠，有时还误事。但是话虽如此，谁能说自己可以坚持一直不用手机呢（拒绝杠精搭腔.jpg）？作为科研狗，玩手机误事肯定不是我们的风格，那么我们该怎么武装自己的手机和平板，让它更有实用性和战斗力呢？接下来本科研狗就给大家简单介绍几款手机和平板上可以用的 App，让我们的科研更具有效率~首先是一款多功能生物狗专用计算器——Biomath。其提供了分子生物学实验所必需的一系列功能，包括核酸和蛋白质浓度转换，核苷酸解链温度计算，摩尔浓度和稀释计算等。图片来源：App 官网截图接下
Measuring APP Carboxy-Terminal Fragments
The accumulation of the amyloid-β (Aβ) peptide in the form of insoluble fibrillar deposits and soluble oligomeric aggregates is widely believed to play a causal role in Alzheimer’s disease (AD). Proteolytic cleavage of APP by the β-site APP
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