WKYMVm (trifluoroacetate salt)

FPR1和FPR2的合成肽激动剂；在0.1nM浓度下诱导转染FPR1或FPR2的ETFR细胞中的钙动员；刺激单核细胞、树突状细胞和NK细胞的趋化性，以及体外单核细胞和中性粒细胞中的超氧化物产生；在8mg/kg剂量下逆转DSS诱发的结肠炎小鼠模型中的粘膜破坏、体重下降和结肠缩短；局部应用可刺激糖尿病皮肤伤口大鼠模型中的血管生成并加速上皮再生和肉芽组织形成。A synthetic peptide agonist of FPR1 and FPR2; induces calcium mobilization in ETFR cells transfected with FPR1 or FPR2 at 0.1 nM; stimulates chemotaxis of monocytes, dendritic cells, and NK cells, as well as superoxide production in monocytes and neutrophils, in vitro; reverses mucosal destruction, decreases in body weight, and colonic shortening in a mouse model of DSS-induced colitis at 8 mg/kg; topical application stimulates angiogenesis and accelerates re-epithelialization and granulation tissue formation in a rat model of diabetic cutaneous wounds.分子式C41H61N9O7S2 • XCF3COOH分子量856.1OC(C=C1)=CC=C1C[C@@H](C(N[C@@H](CCSC)C(N[C@@H](C(C)C)C(N[C@@H](C(N)=O)CCSC)=O)=O)=O)NC([C@H](CCCCN)NC([C@@H](N)CC2=CNC3=CC=CC=C23)=O)=O.OC(C(F)(F)F)=O