Notoginsenoside R1

一种皂苷；以每天25mg/kg的剂量持续8周，可降低以西式饮食喂养的ApoE-/-小鼠血清总胆固醇、三酰甘油和oxLDL水平，并减少动脉粥样硬化病变面积和主动脉根部脂质沉积；以100mg/kg的剂量，可抑制双侧颈总动脉闭塞引起的脑缺血再灌注损伤大鼠模型中海马神经元凋亡并减少梗塞面积；以每天25mg/kg的剂量持续7天，可降低DSS诱导的小鼠结肠炎模型中结肠NF-ĸB和MPO活性以及TNF-α和IL-6水平，并减少结肠缩短、组织损伤和炎症细胞浸润。A saponin; decreases serum total cholesterol, triacylglycerol, and oxLDL levels, as well as reduces atherosclerotic lesion area and lipid deposition in the aortic root of ApoE-/- mice fed a Western diet at 25 mg/kg per day for 8 weeks; inhibits apoptosis of hippocampal neurons and reduces infarct size in a rat model of cerebral ischemia-reperfusion injury induced by bilateral common carotid artery occlusion at 100 mg/kg; decreases colonic NF-ĸB and MPO activities and TNF-α and IL-6 levels, as well as reduces colonic shortening, tissue damage, and inflammatory cell infiltration in a DSS-induced mouse model of colitis at 25 mg/kg per day for 7 days.