Hypotaurine

一种内源性抑制氨基酸；抑制小鼠GAT1、GAT2、GAT3和GAT4（IC50分别为170、240、4.9和8.1μM）和大鼠GAT1、GAT2和GAT3（IC50分别为1,010、52和73μM）对GABA的吸收；抑制表达人类转运蛋白的BGT1nLM(TK-)细胞对GABA的吸收（IC50=380μM）；抑制兔脉络丛切片对钠刺激的GABA的吸收（IC50=21.9μM）；在无细胞测定中清除HOCl和羟基自由基，但不清除超氧化物自由基；在1mM浓度下保护大鼠TR-TBT18d-1胎盘滋养层细胞免受过氧化氢诱导的细胞死亡。An Eendogenous inhibitory amino acid; inhibits GABA uptake by mouse GAT1, GAT2, GAT3, and GAT4 (IC50s = 170, 240, 4.9, and 8.1 μM, respectively) and rat GAT1, GAT2, and GAT3 (IC50s = 1,010, 52, and 73 μM, respectively); inhibits GABA uptake by BGT1 n L-M(TK-) cells expressing the human transporter (IC50 = 380 μM); inhibits sodium-stimulated GABA uptake by rabbit choroid plexus slices (IC50 = 21.9 μM); scavenges HOCl and hydroxyl, but not superoxide, radicals in cell-free assays; protects rat TR-TBT 18d-1 placental trophoblasts from hydrogen peroxide-induced cell death at 1 mM.