FG-7142

具有致焦虑和促惊厥特性的苯二氮卓受体配体；在1μM剂量下可增加原代鸡大脑皮层神经元中苯二氮卓受体配体结合和GABA依赖性氯离子的摄取；在5mg/kg剂量下可减少大鼠对其他动物的压制并增加回避行为；在分别以10和40mg/kg剂量给药时可降低灌注的PTZ癫痫发作阈值并诱发小鼠全身性癫痫；在3.75、7.5和15mg/kg腹腔注射剂量下可减少雌性大鼠的食物和水摄入量、进食率以及在高架十字迷宫开放臂中停留的时间。A benzodiazepine receptor ligand with anxiogenic and proconvulsant properties; increases benzodiazepine receptor ligand binding and GABA-dependent chloride uptake in primary chick cerebral cortical neurons at 1 μM; decreases pinning of the other animal and increases avoiding behavior in rats at 5 mg/kg; reduces the infused PTZ seizure threshold and induces generalized seizures in mice when administered at doses of 10 and 40 mg/kg, respectively; decreases food and water intake, eating rate, and time spent in the open arms of the elevated plus maze in female rats at 3.75, 7.5, and 15 mg/kg, i.p.