Paquinimod

一种免疫调节剂；在EAE小鼠模型中减少Ly6ChiCD115+炎性单核细胞和CD11b+CD11c+树突状细胞的脾脏计数；在肝纤维化的N-IF小鼠模型中以25mg/kg每天的剂量减少肝纤维化以及炎性单核细胞和中性粒细胞的积聚；在NOD小鼠中延迟疾病发作并减少胰岛炎；在系统性硬化症的紧致皮肤1小鼠模型中以5和25mg/kg的剂量减少皮肤厚度、肌成纤维细胞数量和自身抗体产生。An immunomodulator; reduces splenic counts of Ly6ChiCD115+ inflammatory monocytes and CD11b+CD11c+ dendritic cells in a mouse model of EAE; reduces hepatic fibrosis and accumulation of inflammatory monocytes and neutrophils in the N-IF mouse model of liver fibrosis at 25 mg/kg per day; delays disease onset and decreases insulitis in NOD mice; reduces skin thickness, the number of myofibroblasts, and autoantibody production in the tight skin 1 mouse model of systemic sclerosis at 5 and 25 mg/kg.