(E)-Ajoene

具有多种生物活性的二硫化物；对革兰氏阳性菌和革兰氏阴性菌（MIC分别为10-250和150->500µg/ml）以及真菌（MIC分别为15-50µg/ml）有活性；抑制多种癌细胞增殖（IC50分别为18.6-61µM）；在200µM浓度下抑制人类谷胱甘肽还原酶和克氏锥虫锥虫硫酮还原酶；在沙鼠缺血-再灌注损伤模型中具有神经保护作用，在25mg/kg剂量下减少海马CA1区反应性星形胶质细胞增生和微胶质增生。A disulfide with diverse biological activities; active against Gram-positive and Gram-negative bacteria (MICs = 10-250 and 150->500 µg/ml, respectively) and fungi (MICs = 15-50 µg/ml); inhibits proliferation of a variety of cancer cells (IC50s = 18.6-61 µM); inhibits human glutathione reductase and T. cruzi trypanothione reductase at 200 µM; neuroprotective in a gerbil model of ischemia-reperfusion injury, reducing reactive astrocytosis and microgliosis in the hippocampal CA1 region at 25 mg/kg.