Fludioxonil

一种杀菌剂；抑制从草莓和黑莓作物中分离出的灰葡萄孢菌的生长（半数有效浓度EC50为0.06-0.38毫克/升）；抑制酿酒酵母AF293和白色念珠菌IFO1385的生长；是雌激素受体α（ERα）激动剂（在酵母报告基因检测中，半数有效浓度EC50为3.7微摩尔）；在体外可诱导致癌性微小核糖核酸miR-21的表达，抑制雌二醇诱导的增殖，并降低MCF-7乳腺癌细胞的运动能力。A fungicide; inhibits the growth of B. cinerea isolates from strawberry and blackberry crops (EC50s = 0.06-0.38 mg/L); inhibits the growth of S. cerevisiae AF293 and C. albicans IFO1385; an ERα agonist (EC50 = 3.7 μM in a yeast reporter assay); induces expression of the oncogenic microRNA miR-21, inhibits estradiol-induced proliferation, and reduces cell motility of MCF-7 breast cancer cells in vitro.