- 询价
- Cell Signaling Technology
- 4019
- USA
- 2025年08月30日
- W, IHC-P, IF-F, IF-P
- H,M,R,B
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- 详细信息
- 技术资料
- 抗体英文名：
Tau (Tau46) Mouse mAb
- 抗原：
native bovine tau and the epitope maps to the carboxy-terminus of the protein
- 应用范围：
W, IHC-P, IF-F, IF-P
- 级别：
详见MSDS文件
- 保质期：
详见说明书
- 供应商：
CST
- 库存：
大量
- 适应物种：
H,M,R,B
- 是否单克隆：
1
- 保存条件：
-20°c
- 规格：
40 ul (4 western blots)/100 ul (10 western blots)/carrier free & custom formulation / quantity
| 规格： | 产品价格： | ￥请询价 | |
|---|---|---|---|
| 规格： | 40 ul (4 western blots) | 产品价格： | ￥请询价 |
| 规格： | 100 ul (10 western blots) | 产品价格： | ￥请询价 |
| 规格： | carrier free & custom formulation / quantity | 产品价格： | ￥请询价 |
pathway more info application references datasheet PDF MSDS PDF protocols
Applications Key: W=Western Blotting IHC-P=Immunohistochemistry (Paraffin) IF-F=Immunofluorescence (Frozen) IF-P=Immunofluorescence (Paraffin)
Reactivity Key: H=Human M=Mouse R=Rat B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on 100% sequence homology.
| Applications | Reactivity | Sensitivity | MW (kDa) | Isotype |
|---|---|---|---|---|
| W IHC-P IF-F IF-P | H M R (B) | Endogenous | 50 to 80 | Mouse IgG1 |
| Protocols |
|
|---|---|
| Specificity / Sensitivity | Tau (Tau46) Mouse mAb detects endogenous levels of total tau protein and also cross-reacts with MAP2 at 280kD. Tau (Tau46) Mouse mAb is predicted to detect all six isoforms of tau based on the amino acid sequence. |
| Source / Purification | Monoclonal antibody is produced by immunizing animals with native bovine tau and the epitope maps to the carboxy-terminus of the protein. Western Blotting
Western blot analysis of extracts from mouse and rat brain, using Tau (Tau46) Mouse mAb. IHC-P (paraffin)
Immunohistochemical analysis of paraffin-embedded Alzheimer's brain, using Tau (Tau46) Mouse mAb. IF-F
Confocal immunofluorescent analysis of mouse dentate gyrus stained with Tau (Tau46) Mouse mAb (red) and CREB (86B10) Mouse mAb #9104 (blue). IF-P
Confocal immunofluorescent analysis of human Alzheimer brain (A) labeled with Tau (Tau46) Mouse mAb (green) and APP Antibody #2452 (red) compared to normal human brain (B). |
| Background | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by Erk, GSK-3, and CDK5 (1,2). Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease; these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation at Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other neurodegenerative diseases, collectively known as tauopathies (1,3). |
| Application References |
Have you published research involving the use of our products? If so we'd love to hear about it. Please let us know ! |
| Companion Products |
For Research Use Only. Not For Use In Diagnostic Procedures. |
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